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However, only pimitespib, an oral inhibitor developed by Taiho Pharmaceutical, was approved in Japan in 2022 for gastrointestinal stromal tumors, and it is currently the focus of a phase I study for the treatment of solid tumors in the EU and USA [7, 8]

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Given that oxidative stress and inflammatory damage peak early in critical illness and trauma, delayed selenium administration may limit its protective effects

Its mode of action is especially advantageous for individuals with sensitive skin or those primarily seeking to diminish redness associated with AN (23, 24, 26)