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Polymer micelles exhibit remarkably low cytotoxicity in vivo because, following the disintegration of drug-loaded micelles, individual polymer chains are formed that can be excreted through renal metabolism [73]

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doi: 10.1111/hel.12014 29 ChenJ.YeL.JinL.XuX.XuP.WangX.et al

Isa K, Oka K, Beauchamp N et al (2016) Safety assessment of the Clostridium butyricum MIYAIRI 588 probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo