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Figure 1 Figure 2 Abnormal phosphorylation of human tau (hTau) by both non-proline and proline kinases results in insoluble and misfolded tau, leading to the aberrant accumulation and aggregation of filamentous tau polymers, known as paired helical filaments (PHFs) and neurofibrillary tangles (NFTs), two features of CTE (74)

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For example, the Duoxuekang capsule can regulate the mitogen-activated protein kinase (MAPK) signaling pathway, reduce whole-blood viscosity, decrease oxidative damage, and improve brain injury-related complications of high-altitude polycythemia ( Rhodiola and Saussurea involucrata , have demonstrated good anti-hypoxia and neuroprotective effects (Wang et al., 2019)

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