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Why this happens Both drugs have a 'sedating' effect on the brain and central nervous system

While the evidence is somewhat mixed, a recent review concluded that vitamin B12 supplementation can delay the onset of depression and improve the effectiveness of antidepressants. Supplementing with vitamin B12 appears to be a fairly straightforward approach for trying to improve mood

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There are also medications that can change the acidity of the urine, and by alkalinizing the urine in such a case the risk of kidney stone can be decreased (uric acid is more soluble in alkaline medium, so less likely to crystallize)