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TT chem -seq showed reduced nascent transcript levels and slightly increased Pol II stalling in PHF3 KO and SPOC cells (Fig

Synthesis of tert -Butyl (R)-(1-(4-([1,2,4]triazolo[4,3-a]quinolin-7-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (8a) tert Intermediate 6a was treated with commercial compound 7a according to general procedure 8a-8u