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In conclusion, while current therapeutic approaches provide some relief in managing DCM, interventions targeting the diseases core pathological mechanisms require further investigation

Rethinking the pathogenesis of hepatitis B virus (HBV) infection

Poll -/- Polm -/- Polb -/- ( PolX -/- ) MEFs were derived from previously described Poll -/- Polm -/- MEFs 21 by introduction of SpCas9-sgRNA targeting exon 7 of Polb (Supplementary Table 1 and Supplementary Fig

These assays utilize a proprietary membrane-permeant fluorescent dye that passively enters live cells and selectively targets the nicks in DNA that form during apoptosis