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Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats

Adjusting the table to a Trendelenburg position can, in certain instances, facilitate the deepening of the AC by utilizing gravity to displace intraocular contents posteriorly ( Utilization of Eye Speculum: Choosing a suitable speculum for patients with deep-set eyes to guarantee complete visibility of the surgical area while avoiding excessive strain on the globe ( A secondary device (e.g., chopper or cyclodialysis spatula) is employed to stabilize the globe or retract tissue, which may be essential for enhanced control ( Decreasing vitreous pressure Honan Intraocular Pressure Reducer: The Honan balloon is a device applied externally to the eye to provide gentle compression, thereby reducing IOP before surgery ( Preoperative Intravenous Mannitol: Mannitol is an osmotic diuretic administered intravenously to decrease IOP by drawing fluid out of the vitreous body ( Limited Anterior Vitrectomy: This surgical procedure involves removing a portion of the anterior vitreous to alleviate vitreous pressure, particularly in cases where vitreous prolapse occurs during cataract surgery or other anterior segment procedures ( Hyperopic eyes with a shallower anterior chamber and positive posterior pressure may respond less favorably to peribulbar or retrobulbar anesthesia due to increased risk of globe compression and shallow chamber collapse

Wagner and Knig, 2012

doi:10.1084/jem.20092506