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L-theanine combined with luteolin could prevent symptoms similar to Alzheimers disease (AD) in rat models injected with amyloid- (2535) into the hippocampal CA1 region, and this was mainly associated with the improvement of hippocampal insulin signaling, norepinephrine metabolism, and the mitigation of neuroinflammation (48)

Bifidobacterium species, on the other hand, are among the first beneficial bacteria to settle in the gut after were born 11

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The substance is, however, on the WADA prohibited list and is banned in competitive sport [6](#ref-6)