The clinical evidence base supports its use as a tool for maintaining antioxidant status, supporting liver and immune function, and reducing oxidative burden, particularly in individuals whose endogenous production is compromised by age, chronic stress, illness, or inadequate nutrient precursor availability
Deconvolution of bulk methylation has characterized broad immunological clusters and high-level cell states, such as nave or memory, resting or activated, and macrophage polarization status across meningioma grades, and suggested broad immune suppression associated with myeloid cell enrichment, and a low frequency of T cells
In middle-aged mice on an HFD, 8 months of UA supplementation improved spontaneous exercise and grip strength, and 6 weeks of treatment boosted running endurance in aged mice
Physiological fatigue corresponds to a homeostatic process, selected by evolution for its usefulness, whereas pathological fatigue unravels a dyshomeostatic state, which reflects a combined dysfunctioning of numerous potential systems, revealed by both physiological issues (chronic inflammation, mitochondrial dysfunctioning, cardio-pulmonary pathologies, endocrinopathies, vitamin deficiencies) and interoceptive processes, with inappropriate corrections by the brain of biological perturbations
