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It should be noted, however, that the methylene-tetrahydro-folate-reductase (MTHFR) enzyme reduces 5,10-methylene THF to 5-methyl THF and only functions when vitamin B12 is present as a cofactor (Fig

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Many sources apply allometric scaling from rodent doses (commonly 10 mcg/kg in rat studies) and arrive at a human equivalent, then quietly round to convenient vial sizes