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Additionally, research has shown a direct impact of oral functions, such as mastication and swallowing, on life expectancy

Chronic inflammation, infection, gastrointestinal dysfunction, diabetes, dehydration, mitochondrial stress and toxic exposure can increase the burden of frequently acidic metabolites and other compounds that must be processed and eliminated

According to the race, these studies could be classified into 5 subgroups, Africans(68 studies), Asians(20 studies) , Caucasians(5 studies), Indians(10 studies) and mixed populations(14 studies)

Dysregulation of nitric oxide synthases during early and late pathophysiological conditions of diabetes mellitus leads to amassing of microvascular impedement