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Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome

Narula N, Lillemoe HA, Caudle AS, Chemaly RF, Anderson JJ, Segal C, Porter CA, Swisher SG , Levenback CF, Aloia TA

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This reduction in ZIP6 expression is associated with increased resistance to hypoxic conditions and facilitates the process of epithelialmesenchymal transition (EMT), which is closely related to cancer progression and metastasis (Takatani-Nakase, 2018[408])