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Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)

Vitamin A is essential for the developing CNS where it affects neurogenesis and neuronal patterning, but keeps playing an important role in the adult brain by regulating neuroplasticity in cerebral structures [100]

Thromb Res (2022) 213 Suppl 1:S3535S41

Therefore, an antioxidant substance with strong ROS scavenging capabilities represents a potential candidate for treating UVB-induced skin damage or photoaging 14