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Immunofluorescence (IF) studies indicated that those transplanted GMSCs integrated into the wall matrix of NPs and localized in the peripheral areas outside of the injured nerves as recognized by the positive expression of human nuclei, whereas only about 5% of them were positively stained for the active form of caspase-3 (Additional file 1: Fig

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Recent evidence suggests that a number of these manifestations may be linked to an unfavorable impact of the disease on the mitochondrial function of various tissues and organs (18,22)