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Potency of olorofim (F901318) compared to contemporary antifungal agents against clinical Aspergillus fumigatus isolates, and review of azole resistance phenotype and genotype epidemiology in China

While dysregulated iron metabolism is one of the features in cancer cells driving heightened influx and decreased efflux of iron from tumour cells, it is unclear if this imbalance precedes the cancerous transformation or is a consequential response to cancer, aiding as an adaptive step for maintenance and progression of malignancy

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It has been shown that ETC Complex II genes such as sdh1 + are not strongly repressed by mitochondrial dysfunction (Malecki et al, 2016)