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PLs mechanisms of action include the promotion of the p53 suppressor gene expression, modulation of inflammatory cytokines, upregulation of endogenous antioxidant systems, and blockade of UV radiation-induced cyclooxygenase2 expression (Nestor et al., 2014, Siscovick et al., 2008)

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If they still have bloating or other GI symptoms, we discontinue Category 2 and try Category 3, starting with a half dose and gradually increasing to 26 billion CFU