glutathione oxidation mechanism Tumor-targeted catalysis with ruthenium nanoreactors against hypoxic osteosarcoma Glutathione Pathways

doi: 10.1186/s12888-025-06490-3 11

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Proposed mechanisms demonstrated in previous studies include increased oxidative stress, mtDNA and nDNA genetic mutations, age-related vulnerability, pathway dysfunction, and signaling dysregulation (Chrysostomou et al., 2013

The hFSP1-bound FAD can be converted to 6-hydroxy-FAD by hFSP1 during aerobic turnover with NADPH in vitro 20