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doi: 10.1186/s13023-021-01732-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 139

At approximately 7 days, semaglutide reaches steady-state plasma concentration after 4 to 5 weeks of weekly administration

Oridinon (Ori), a natural terpenoid derived from the plant Isodon rubescens (Hemsl.), can increase cardiac Gln levels and inhibit the decline of ATP/ADP ratio, protecting cardiomyocytes and reducing infarct size in a rat model of myocardial injury