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barbarum directly promotes the conversion of muscle fiber types by activating CREB and upregulating the expression of ERR, which facilitates the transcription of its downstream genes ( MEF2 , Myh IIx ) to form type IIa muscle fibers (84)

A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer

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Currently, the cloning of the specific proteins that facilitate urea transport in certain tissues has had a radical effect on our understanding of the physiologic importance of that molecule