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Simultaneous quantification of arachidonic acid metabolites in cultured tumor cells using high-performance LC/electrospray ionization tandem MS

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Similarly, a prior study has shown that MB is more toxic in tumor cell lines, presenting EC 50 20,000 folds higher in normal PBMCs compared to tumor cell lines ( 50 of 11 M (3,530 g/mL) in PBMCs, only a slight reduction in cell viability was found at 20 M