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Mutations of COP1 (residues K472G/H578A/Y491G) abolished its interaction with c-Jun, as demonstrated by co-transfection and reciprocal pull-down assays (Fig

All patients were provided informed consent and screening remotely via phone interview, educated via online animated presentation, and e-consented via REDCap electronic data capture tools hosted at the Ohio State University Medical Center that incorporated questions from the REDCap Shared Library 53,54