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The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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Peptide therapy is increasingly used by bodybuilders, athletes, and individuals experiencing age-related muscle loss to enhance training results, shorten recovery time, and improve body composition

Some research observations also note occasional lightheadedness , which may be related to vascular or vasodilatory effects in certain models