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Citation45 SLC7A5 inhibitor treatment suppressed allergen-induced skin inflammation in both ovalbumin (OVA)-immunized and OVA-specific Th2 cell-transferred mice and effectively suppressed allergen-induced airway and nasal hyperresponsiveness in immunized and/or Th2-transferred mice

Research suggests it may interact with the Beta-3 adrenergic receptors found in fat cells, enhancing the signals that initiate fat breakdown, particularly in stubborn visceral and abdominal fat depots

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These results show that pharmaceutical modification can protect Sub-A, and likely other glutenases, from auto-digestion as well as from acid inactivation in the stomach, thus rendering the enzyme more effective for applications in vivo