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The potential disadvantage is that IGF-1 levels may decline more noticeably during the full week off compared to the minimal decline during 2-day breaks, and some patients report mild regression in sleep quality during the off week before benefits rapidly resume when therapy restarts

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Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-, TGF-, and FOXL-2