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22,35 This will decrease the risk of dysbiosis, lower plasma levels of urea and uremic toxins, and help to slow down the progression of CKD

This process is frequently mediated by histone acetyltransferases (HATs), which add acetyl groups to histones, loosening the chromatin structure and facilitating gene transcription (78)

Phase I and phase II trials are also underway to assess the safety and pharmacokinetics of small molecule inhibitors of LOXL2, such as GB2064 (NCT04679870) and PXS-5382 A (NCT04183517)