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Probes utilized in these studies include small-molecule fluorophores and fluorescents for bioimaging, including the classic fluorescent labeling dyes, 3,3-diethyloxacarbocyanine iodide (DiOC 2 ), rhodamine 123 (Rh123), and calcein acetoxymethyl (229)

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Care should be taken to prevent any flammable materials being present near the focal point of the IR beam

Therefore, various strategies to improve their therapeutic efficiency (application of other anticancer effects of cyanine dyes, improvement in the tumor selectivity of cyanine dyes and their combination with other therapeutic agents and therapies) are intensively studied