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15 week old ZDF rats displayed hyperglycemia, MNCV and SNCV deficits, thermal and mechanical hypoalgesia, tactile allodynia, and 26% loss of intraepidermal nerve fibers

Kwiecien S, Jasnos K, Magierowski M, Sliwowski Z, Pajdo R, Brzozowski B, Mach T, Wojcik D, Brzozowski T (2014) Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress-induced gastric injury

A large plant may have many separate pieces of process equipment and thousands of drip traps discharging condensate into the condensate return lines