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Considering the recent X-ray crystallography and cryo-EM data, which revealed that GSH and Glu could bind to different domains of GLR3.4 for ion channel activation 30 , it would be intriguing to investigate whether GSH binds to GLR3.3 and further determine the potential relationship between GSH and Glu in activating GLR3.3

Decoys can be used as therapeutic agents, either to inhibit the expression of genes that are activated by a transcription factor, or to upregulate genes that are suppressed by the binding of a transcription factor

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Moreover, Ido1 is induced by the pro-inflammatory cytokine interferon gamma, whereas anti-inflammatory cytokines including IL-10 and transforming growth factor (TGF) inhibit Ido1, thus, activity of Ido1 in IECs reflects the balance between pro- and anti-inflammatory signals 171