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However, there was a significant 40% reduction in the sporozoites of salivary glands from GSKO-infected mosquitoes in comparison with WT-infected mosquitoes (Fig

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BENEFITS Antioxidant defense studied as a primary intracellular scavenger of reactive oxygen species (ROS) Redox balance investigated for its role in maintaining the cellular GSH/GSSG ratio Detoxification research examined as a cofactor in phase II conjugation and xenobiotic clearance Cysteine delivery studied as a transport and storage form of bioavailable cysteine Cellular protection explored in models of oxidative and electrophilic stress WHAT RESEARCHERS LOOK AT GSH/GSSG ratio as a marker of cellular redox state Glutathione peroxidase and glutathione reductase enzyme activity Conjugation reactions catalyzed by glutathione S-transferases Mitochondrial glutathione pools and oxidative-stress resistance Depletion and repletion kinetics in cell-culture models

Therefore, the specific mechanism of TST-regulating STAT3 and p-STAT3 needs to be confirmed by further experiments