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See a doctor if you experience: Persistent fatigue Tingling or numbness Memory issues Balance problems Shortness of breath Unexplained weakness Also seek medical advice before taking high-dose B12 long-term, especially if you have existing health conditions

Most peptides degrade rapidly in the stomach and intestines, so oral preparations typically provide negligible systemic availability, generally less than 2%

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At 24 h after administration, the mean concentrations of total radioactivity in the kidney, thymus, liver, spleen, and gastric wall decreased significantly but were still higher than the mean concentrations in the plasma at the same time