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Additionally, around 12% of oxygen used in mitochondrial metabolism produces free radicals, which can lead to oxidative stress and even DNA damage [2]

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[DOI] [PubMed] [Google Scholar] 146.Taylor FL, Levine LA

Highlighting the potential of this approach, several recent translational and clinical studies beyond the field of MS used this method of delivery and were able to clear intracellular tau pathology in tauopathy mice by intranasal application of an anti-tau-antibody (144) or reduce apathy in frontotemporal dementia patients by intranasal application of oxytocin (149) ( Figure 2C )