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Specifically, the renoprotection effects of Tanshinone IIA and Ganoderic acid A were consistent with the previous works ( While the mechanism of UA reduction is linked to various factors, including the inhibition of XOD activity, anti-inflammatory and antioxidant effects, the interaction of transport regulation mechanisms holds a pivotal role ( In vitro experiments involving the heterologous expression of ABCG2 have confirmed that, in the presence of adenosine triphosphate (ATP), ABCG2 mediates urate transport ( 5 Conclusion This study demonstrated the therapeutic effect of Wuling capsule on HUA both in vivo and in vitro , primarily by protecting liver and kidney function, improving the regulation of cell apoptosis, and regulating UA-related transporters in the kidney to reduce serum UA levels

R.VyazovskiyV

Author contributions Conceptualization, AM, HV, and LM

Riboflavin supplementation resulted in clinical improvements in nine of ten patients treated [34,39-42,44,45]