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In patients with underlying systemic vasculitis, immunosuppressive medications (azathioprine, methotrexate, mycophenolate mofetil), biologics, or plasma exchange can be considered

Targeting NLRP3 inflammasome activation has direct translational relevance: the small-molecule inhibitor MCC950 ameliorates albuminuria, glomerulosclerosis, and podocyte injury in db/db mice by blocking caspase-1/IL-1 maturation

To the 10.000 rpm supernatant containing microsomes and cytosol fractions, 0.2 volume of 0.1 M calcium chloride solution was added, and further centrifuged at 10,000 rpm for 10 minutes to precipitate the microsomes