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All but the most severe of cases can be successfully managed through lifestyle changes in diet and physical activity alone, although low compliance has encouraged interest in effective therapies, including gastrointestinal surgery (efficacious and long-lasting, but limited in use because of associated risks and costs) and pharmacological interventions

Others take longer

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Alimta Dosage and Administration 2.1 Recommended Dosage for Non-Squamous NSCLC The recommended dose of ALIMTA when administered with pembrolizumab and platinum chemotherapy for the initial treatment of metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes administered after pembrolizumab and prior to carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles