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10.1172/JCI60610 197 OlleroM.GuerreraI

The mechanism of action differs between iron chelators, with DFO exerting a direct effect by inducing autophagy to promote ferritin degradation in the lysosome, while L1 and DFX may chelate intracellular free iron and take iron from ferritin before proteases break it down (Temraz et al., 2014)