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Harnessing the mitochondrial integrity for neuroprotection: Therapeutic role of piperine against experimental ischemic stroke

The POR pathway induces lipid peroxidation and ferroptosis in the cells expressing low levels of ALOXs, indicating that targeting POR or CYB5R1 is liable to a more potential therapeutic approach [58]

Additionally, immunofluorescence revealed that CXCL10 antibody treatment in the CM group significantly reversed the MCA205 tumor-induced increase in pro-inflammatory M1 macrophage levels (Fig