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Nat Cell Biol 2012

In the study of SARD, ML has proven useful in developing prediction models for diagnosis and disease outcomes and in elucidating pathogenesis [reviewed in (185)]

Further, an LPS administration model of systemic inflammation in sepsis in conjunction with convulsant PTZ treatment in mice increased seizure susceptibility, which was attenuated with NOX2 genetic ablation and inhibition ( Epileptic encephalopathies and genetic epilepsies such as West, Lennox-Gastaut, Dravet, Lafora, and Leigh syndromes have additionally shown evidence of gliosis and neuroinflammation in humans (You et al., 2009