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Today, cancer is considered to be a complex multistep disorder, the result of a combination of factors including exposure to radiation and/or carcinogens (damage to DNA), infection, genetics, aging, immune function disorders, and lifestyle factors such as smoking (Nelson et al

Archivado desde el original el 28 de abril de 2009

Here, we present a novel mechanism by which TNBC cells of the MSL/CL subtype activate an OS response through direct induction of the NRF2 pathway by Cyss uptake, and we propose NRF2 and its direct transcriptional target OSGIN1 as interesting targets for personalized cancer treatment

Pierre Magistrettis laboratory has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by revealing the key role that glial cells, in particular astrocytes, play in this physiological process