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10.1093/cercor/bhy196 Summary Keywords epilepsy, astrocytes, glutamate transporters, metabotropic glutamate receptors, GLT-1, GLAST, mGluR3, mGluR5 Citation Peterson AR and Binder DK (2020) Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

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For example, we and others have found that renal cancer cells (RCC) with loss of VHL (Von Hippel-Lindau), a tumor suppressor that destabilizes HIF1A via ubiquination, are significantly sensitive to ascorbate treatment compared to VHL-proficient cells