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Disrupted peripheral neurogenic signaling pathways between the liver and the brain axis, coupled with perturbed central neurotransmission within the brain, in tandem with disease-related or disease-associated factors, such as complications, treatments, and severity, as well as alcohol use, metabolic syndrome, and malignancy, collectively contribute toward clinical fatigue (10)

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You may even have a tingling sensation in your hands or feet, jaundice (a yellowing of the skin and eyes), problems with your vision, or become easily depressed

Nearly all liver-specific Gclc L-KO mice survived over time (Fig