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Based on the conformational changes of the androgen receptor ligand binding domain induced by androgens or anti-androgens, it can be concluded that the different transcriptional activities displayed by either full agonists (testosterone, 5-dihydrotestosterone, methyltrienolone), partial agonists (RU486 and CPA) or full antagonists (hydroxyflutamide, bicalutamide, enzalutamide) are the result of recruitment of a different repertoire of co-regulators (coactivators or corepressors) as a consequence of these conformational changes

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Comment: One commenter supported the proposal but urged CMS to consider an approach that would ensure no ACOs are negatively impacted

Grip it with your hands close together somewhere around 4 to 6 inches apart palms facing you