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Daratumumab triggers CD38 + multiple myeloma cells [via antibody-dependent cellular cytotoxicity (ADCC), complement dependent cytotoxicity (CDC), and tumor-associated macrophages (TAMs)] in sensitive and drug-resistant patients, regulates the enzyme activity of CD38, reduces the level of adenosine and reduces adenosine-induced immunosuppression

Not as an independent driver of weight loss the evidence for that is weak

Vegetarians and vegans are particularly at risk of this deficiency, as they do not consume animal-derived foods that are rich in Vitamin B12

What is Vitamin B12 Vitamin B12 supports DNA synthesis, red blood cell formation, neurological function, and overall metabolic health