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From a translational perspective, a recent study found a positive correlation of TREM2 expression levels in AT with BMI only in males and between a specific TREM2 polymorphism and BMI in female individuals 57

After three months of cyclic senescent cell removal using D+Q, we assessed cerebral blood flow, brain volume and ventricle volume with MRI to determine if removing senescent cells produced global effects on brain function and structure

This is particularly important since BRAF V600E expression in Ink4a/Arf-deleted cells has been shown to increase the proportion of proliferative glial progenitor cells in adult mice in vivo , disrupt asymmetric cell division of OPCs, and increase OPC frequency in vitro at the expense of mature oligodendrocytes and astrocytes, respectively, without altering NSC frequency ( V600E expression and Ink4a/Arf loss than NSCs