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A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]

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However, long-term BG00011 exposure induced acute exacerbations and inflammation, leading to reduced survival rates, and the drug was ultimately discontinued from clinical development ( Given these setbacks in novel drug development, alternative strategies such as drug repurposing have gained traction in IPF research