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This mechanistic comparison, particularly the predicted prominence of the oxidative pathway for TAM and toremifene will be a critical area for future investigation

10.19106/jmedsci004804201604 16 RussellM

When evaluated in patients with KOA, a multi-center trial containing a total of 207 participants with symptomatic KOA were randomly assessed after receiving either oral methotrexate (1025 mg weekly) or a matched placebo over 12 months while continuing their usual analgesia