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Table 1 shows some major endogenous and exogenous sources of reactive species

doi: 10.1016/j.lfs.2005.05.095

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Phase I Block (Depolarizing Block) Activation of nACh receptors causes membrane depolarization Transient, random muscle fasciculations of varying duration and intensity occur in 94% of patients (Renew, 2026) 5) Continuous membrane depolarization causes inactivation of sodium channels The muscle membrane becomes unresponsive to acetylcholine within 1-2 minutes after i.v