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[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)

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Dringen 2000)

Epitalon also appears to modulate gene expression , particularly those related to oxidative stress response and inflammation both of which are critical components in the development of age-associated diseases