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AKT activation because of PTEN loss upregulates xCT via GSK3 NRF2, leading to inhibition of ferroptosis in PTEN mutant tumor cells: Cell Reports Glutathione biosynthesis pathway and glutathione ascorbate cycle For Download Scientific Diagram Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy Natural Compounds and Glutathione: Beyond Mere Antioxidants
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