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The structural change ( Figure 7E ) could potentially hinder the transamination reaction, because the loop movement might bring the -amino group of PMP into closer proximity to other amino-acid side groups, such as His192, promoting the hydrogen bond formation that may influence the reactivity of PMP with GSA

Related to inflammation, the NF-B signaling pathway is also activated in obesity and is responsible for the production of pro-inflammatory cytokines such as TNF- that induce insulin resistance (139)

Nevertheless, one UK study reported a much higher rate of 71.3%

A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease Poladian, N., et al