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Accumulation of mtDNA damage is particularly detrimental and has been implicated in the pathogenesis of NDDs such as AD, PD, HD, and ALS

Progesterone is also a substrate of the 5-reductase-2 isoenzyme, which converts it to dihydroprogesterone, a hormone that in turn competes with testosterone and DHT for the androgen receptor (12)

Separation was carried out using a gradient method, at ambient temperature and a flow rate of 0.3 mL/min (see below for more information)

Whether pain management is best accomplished by the primary treating clinician and/or by a multidisciplinary team or other pain specialists should be determined by the individual clinician in consultation with the patient